BAMLET (Bovine α-lactalbumin made lethal to tumor cells) inhibits autophagy flux and induces apoptosis via down-regulation of protein kinase CK1α and attenuation of the AKT/p-ß-catenin (S552) pathway in RAS-mutated human colorectal HCT 116 cells

OBJECTIVE(S): Oncogenic RAS mutations occur in nearly 50% of colorectal cancer cases and are usually dependent on the autophagy mechanism to maintain tumorigenesis. We have recently demonstrated that CK1α controls autophagy machinery possibly through the AKT/p-ß-catenin (S552) signaling in colorecta...

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Detalles Bibliográficos
Autores principales: Behrouj, Hamid, Mokarram, Pooneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510486/
https://www.ncbi.nlm.nih.gov/pubmed/37736507
http://dx.doi.org/10.22038/IJBMS.2023.69343.15114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510486/
https://www.ncbi.nlm.nih.gov/pubmed/37736507
http://dx.doi.org/10.22038/IJBMS.2023.69343.15114

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