Dose–Response Activity-Based DNA-Encoded Library Screening

[Image: see text] Dose–response, or “conforming” behavior, increases confidence in a screening hit’s authenticity. Here, we demonstrate dose–response solid-phase DNA-encoded library (DEL) screening. Compound dose in microfluidic droplets is modulated via the UV intensity of photocleavage from DEL be...

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Detalles Bibliográficos
Autores principales: Fitzgerald, Patrick R., Cochrane, Wesley G., Paegel, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510511/
https://www.ncbi.nlm.nih.gov/pubmed/37736190
http://dx.doi.org/10.1021/acsmedchemlett.3c00159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510511/
https://www.ncbi.nlm.nih.gov/pubmed/37736190
http://dx.doi.org/10.1021/acsmedchemlett.3c00159

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