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Dose–Response Activity-Based DNA-Encoded Library Screening

[Image: see text] Dose–response, or “conforming” behavior, increases confidence in a screening hit’s authenticity. Here, we demonstrate dose–response solid-phase DNA-encoded library (DEL) screening. Compound dose in microfluidic droplets is modulated via the UV intensity of photocleavage from DEL be...

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Detalles Bibliográficos
Autores principales:	Fitzgerald, Patrick R., Cochrane, Wesley G., Paegel, Brian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510511/ https://www.ncbi.nlm.nih.gov/pubmed/37736190 http://dx.doi.org/10.1021/acsmedchemlett.3c00159

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