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Toward a molecular mechanism for the interaction of ATP with alpha-synuclein

The ability of Adenosine Triphosphate (ATP) to modulate protein solubility establishes a critical link between ATP homeostasis and proteinopathies, such as Parkinson's (PD). The most significant risk factor for PD is aging, and ATP levels decline dramatically with age. However, the mechanism by...

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Detalles Bibliográficos
Autores principales: Kamski-Hennekam, Evelyn Rose, Huang, Jinfeng, Ahmed, Rashik, Melacini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510630/
https://www.ncbi.nlm.nih.gov/pubmed/37736631
http://dx.doi.org/10.1039/d3sc03612j