Proximity-Induced Ligation and One-Pot Macrocyclization of 1,4-Diketone-Tagged Peptides Derived from 2,5-Disubstituted Furans upon Release from the Solid Support

[Image: see text] 1,4-Dione-containing peptides are generated during the cleavage of 2,5-disubstituted furan-containing systems. The generated electrophilic systems then react with α-effect nucleophiles, following a Paal-Knorr-like mechanism, for the generation of macrocyclic peptides, occurring aft...

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Detalles Bibliográficos
Autores principales: Manicardi, Alex, Theppawong, Atiruj, Van Troys, Marleen, Madder, Annemieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510716/
https://www.ncbi.nlm.nih.gov/pubmed/37656900
http://dx.doi.org/10.1021/acs.orglett.3c02289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510716/
https://www.ncbi.nlm.nih.gov/pubmed/37656900
http://dx.doi.org/10.1021/acs.orglett.3c02289

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