Tuning Methylation-Dependent Silencing Dynamics by Synthetic Modulation of CpG Density

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[Image: see text] Methylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific loci was shown to be sufficient to silence synthetic and endogeno...

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Detalles Bibliográficos
Autores principales: Ma, Yitong, Budde, Mark W., Zhu, Junqin, Elowitz, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510725/
https://www.ncbi.nlm.nih.gov/pubmed/37572041
http://dx.doi.org/10.1021/acssynbio.3c00078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510725/
https://www.ncbi.nlm.nih.gov/pubmed/37572041
http://dx.doi.org/10.1021/acssynbio.3c00078

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