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Tuning Methylation-Dependent Silencing Dynamics by Synthetic Modulation of CpG Density
[Image: see text] Methylation of cytosines in CG dinucleotides (CpGs) within promoters has been shown to lead to gene silencing in mammals in natural contexts. Recently, engineered recruitment of methyltransferases (DNMTs) at specific loci was shown to be sufficient to silence synthetic and endogeno...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510725/ https://www.ncbi.nlm.nih.gov/pubmed/37572041 http://dx.doi.org/10.1021/acssynbio.3c00078 |
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