Cargando…

Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol

[Image: see text] An efficient gram-scale synthesis of the antituberculosis agent pretomanid using straightforward chemistry, mild reaction conditions, and readily available starting materials is reported. Four different protecting groups on the glycidol moiety were investigated for their technical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lucas, Tobias, Dietz, Jule-Philipp, Cardoso, Flavio S. P., Snead, David R., Nelson, Ryan C., Donsbach, Kai O., Gupton, B. Frank, Opatz, Till
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510727/ https://www.ncbi.nlm.nih.gov/pubmed/37736135 http://dx.doi.org/10.1021/acs.oprd.3c00187

Ejemplares similares

Population Pharmacokinetics of the Antituberculosis Agent Pretomanid
por: Salinger, David H., et al.
Publicado: (2019)

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
por: Lucas, Tobias, et al.
Publicado: (2020)

Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline
por: Robey, Juliana M. S., et al.
Publicado: (2023)

Diastereoselectivity is in the Details: Minor Changes Yield Major Improvements to the Synthesis of Bedaquiline
por: Mear, Sarah Jane, et al.
Publicado: (2022)

Delamanid or pretomanid? A Solomonic judgement!
por: Mudde, Saskia E., et al.
Publicado: (2022)

Baseline and acquired resistance to bedaquiline, linezolid and pretomanid, and impact on treatment outcomes in four tuberculosis clinical trials containing pretomanid
por: Timm, Juliano, et al.
Publicado: (2023)

Internal Doses of Glycidol in Children and Estimation of Associated Cancer Risk
por: Aasa, Jenny, et al.
Publicado: (2019)

Does External Exposure of Glycidol-Related Chemicals Influence the Forming of the Hemoglobin Adduct, N-(2,3-dihydroxypropyl)valine, as a Biomarker of Internal Exposure to Glycidol?
por: Shimamura, Yuko, et al.
Publicado: (2020)

An Exposure-Response Perspective on the Clinical Dose of Pretomanid
por: Nedelman, Jerry R., et al.
Publicado: (2020)

Male reproductive hormones in patients treated with pretomanid
por: Boekelheide, K., et al.
Publicado: (2022)

Pretomanid for tuberculosis treatment: an update for clinical purposes
por: Occhineri, Sara, et al.
Publicado: (2022)

1400. Pretomanid in the Treatment of Patients with Tuberculosis in the United States: the Bedaquiline, Pretomanid and Linezolid (BPaL) Accelerated Monitoring (BAM) Project
por: Goswami, Neela, et al.
Publicado: (2021)

Effect of concentration of glycidol on the properties of resorcinol-formaldehyde aerogels and carbon aerogels
por: Zhu, Xiurong, et al.
Publicado: (2022)

Cu(triNHC)-catalyzed polymerization of glycidol to produce ultralow-branched polyglycerol
por: Sung, Kihyuk, et al.
Publicado: (2023)

Aureolic Acid Group of Agents as Potential Antituberculosis Drugs
por: Bespyatykh, Julia, et al.
Publicado: (2020)

Promise and Peril of Pretomanid–Rifamycin Regimens for Drug-susceptible Tuberculosis
por: Velásquez, Gustavo E., et al.
Publicado: (2023)

Optimization of the Synthesis of Glycerol Derived Monoethers from Glycidol by Means of Heterogeneous Acid Catalysis
por: Pires, Elisabet, et al.
Publicado: (2018)

Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (R)-Glycidol
por: Moriyama, Mizuki, et al.
Publicado: (2020)

Nanocatalyst-Assisted Facile One-Pot Synthesis of Glycidol from Glycerol and Dimethyl Carbonate
por: Elhaj, Elrasheed, et al.
Publicado: (2022)

Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
por: Burmaoğlu, Serdar, et al.
Publicado: (2017)

A partially randomised trial of pretomanid, moxifloxacin and pyrazinamide for pulmonary TB
por: Tweed, C. D., et al.
Publicado: (2021)

Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date
por: Stancil, Stephani L, et al.
Publicado: (2021)

Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid
por: Bateson, Anna, et al.
Publicado: (2022)

Toxicity and toxicokinetic assessment of an anti-tubercular drug pretomanid in cynomolgus monkeys
por: Bruning-Barry, Rebecca, et al.
Publicado: (2022)

Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent
por: Sanusi, Shuaibu Babaji, et al.
Publicado: (2017)

Riminophenazine Derivatives as Potential Antituberculosis Agents: Synthesis, Biological, and Electrochemical Evaluations
por: Bvumbi, Mpelegeng Victoria, et al.
Publicado: (2021)

Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)
por: Baptista, Rafael, et al.
Publicado: (2018)

Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid
por: Thompson, Andrew M., et al.
Publicado: (2017)

Long-Term Effects on QT Prolongation of Pretomanid Alone and in Combinations in Patients with Tuberculosis
por: Li, Hanbin, et al.
Publicado: (2019)

Pretomanid with bedaquiline and linezolid for drug-resistant TB: a comparison of prospective cohorts
por: Oelofse, S., et al.
Publicado: (2021)

Assessment of the Carcinogenic Potential of Pretomanid in Transgenic Tg.rasH2 Mice
por: Ambroso, Jeffrey L., et al.
Publicado: (2022)

Characterizing Absorption Properties of Dispersible Pretomanid Tablets Using Population Pharmacokinetic Modelling
por: Zou, Yuanxi, et al.
Publicado: (2022)

Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents
por: Butman, Hailey S., et al.
Publicado: (2020)

Recent developments of imidazo[1,2-a]pyridine analogues as antituberculosis agents
por: Samanta, Sauvik, et al.
Publicado: (2023)

Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid
por: Gómez-González, Paula J., et al.
Publicado: (2021)

Fed- and Fasted-State Performance of Pretomanid Amorphous Solid Dispersions Formulated with an Enteric Polymer
por: Nguyen, Hanh Thuy, et al.
Publicado: (2023)

Precise Synthesis and Thermoresponsive Property of Poly(ethyl glycidyl ether) and Its Block and Statistic Copolymers with Poly(glycidol)
por: He, Tingyu, et al.
Publicado: (2021)

Deepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicles
por: Wehr, Riccardo, et al.
Publicado: (2020)

Potential Role of Lipase Activity on the Internal Exposure Assessment of Glycidol Released from Its Fatty Acid Esters
por: Shimamura, Yuko, et al.
Publicado: (2023)

Preparation and Boron Removal Performance of Glycidol Modified PANI Nanorods: An Optimization Study Based on Response Surface Methodology
por: Le, Yunlong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2f8l96000usjj2h56ki6bf9pqj