Disease-associated KCNMA1 variants decrease circadian clock robustness in channelopathy mouse models

KCNMA1 encodes the voltage- and calcium-activated K(+) (BK) channel, which regulates suprachiasmatic nucleus (SCN) neuronal firing and circadian behavioral rhythms. Gain-of-function (GOF) and loss-of-function (LOF) alterations in BK channel activity disrupt circadian behavior, but the effect of huma...

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Detalles Bibliográficos
Autores principales: Dinsdale, Ria L., Roache, Cooper E., Meredith, Andrea L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510740/
https://www.ncbi.nlm.nih.gov/pubmed/37728576
http://dx.doi.org/10.1085/jgp.202313357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510740/
https://www.ncbi.nlm.nih.gov/pubmed/37728576
http://dx.doi.org/10.1085/jgp.202313357

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