Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis

Efficient access to the morphinan scaffold remains a major challenge in both synthetic chemistry and biotechnology. Here, a biomimetic chemo-enzymatic strategy to synthesize the natural promorphinan intermediate (+)-salutaridine is demonstrated. By combining early-stage organic synthesis with enzyma...

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Detalles Bibliográficos
Autores principales: Cigan, Emmanuel, Pletz, Jakob, Berger, Sarah A., Hierzberger, Bettina, Grilec-Zlamal, Michael, Steiner, Alexander, Oroz-Guinea, Isabel, Kroutil, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510765/
https://www.ncbi.nlm.nih.gov/pubmed/37736642
http://dx.doi.org/10.1039/d3sc02304d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510765/
https://www.ncbi.nlm.nih.gov/pubmed/37736642
http://dx.doi.org/10.1039/d3sc02304d

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