ATM inhibition augments type I interferon response and antitumor T-cell immunity when combined with radiation therapy in murine tumor models

BACKGROUND: Radiation therapy (RT) elicits DNA double-strand breaks, resulting in tumor cytotoxicity and a type I interferon (IFN) response via stimulator of interferon genes (STING) activation. We investigated whether combining RT with an ataxia-telangiectasia mutated inhibitor promoted these effec...

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Detalles Bibliográficos
Autores principales: Jin, Won Jong, Zangl, Luke M, Hyun, Meredith, Massoud, Elian, Schroeder, Kaleb, Alexandridis, Roxana A, Morris, Zachary S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510866/
https://www.ncbi.nlm.nih.gov/pubmed/37730275
http://dx.doi.org/10.1136/jitc-2023-007474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510866/
https://www.ncbi.nlm.nih.gov/pubmed/37730275
http://dx.doi.org/10.1136/jitc-2023-007474

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