Enhancement of in vivo targeting properties of ErbB2 aptamer by chemical modification

Aptamers have great potential for diagnostics and therapeutics due to high specificity to target molecules. However, studies have shown that aptamers are rapidly distributed and excreted from blood circulation due to nuclease degradation. To overcome this issue and to improve in vivo pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Park, Jun Young, Cho, Ye Lim, Chae, Ju Ri, Lee, Jung Hwan, Kang, Won Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511116/
https://www.ncbi.nlm.nih.gov/pubmed/37729138
http://dx.doi.org/10.1371/journal.pone.0291624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511116/
https://www.ncbi.nlm.nih.gov/pubmed/37729138
http://dx.doi.org/10.1371/journal.pone.0291624

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