CERS6-derived ceramides aggravate kidney fibrosis by inhibiting PINK1-mediated mitophagy in diabetic kidney disease

During diabetic kidney disease (DKD), ectopic ceramide (CER) accumulation in renal tubular epithelial cells (RTECs) is associated with interstitial fibrosis and albuminuria. As RTECs are primarily responsible for renal energy metabolism, their function is intimately linked to mitochondrial quality c...

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Detalles Bibliográficos
Autores principales: Wang, Xiangyu, Song, Minkai, Li, Xiaomin, Su, Cailin, Yang, Yanlin, Wang, Kai, Liu, Cuiting, Zheng, Zongji, Jia, Yijie, Ren, Shijing, Dong, Wenhui, Chen, Jiaqi, Wang, Ting, Liu, Lerong, Guan, Meiping, Zhang, Chao, Xue, Yaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511179/
https://www.ncbi.nlm.nih.gov/pubmed/37458434
http://dx.doi.org/10.1152/ajpcell.00144.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511179/
https://www.ncbi.nlm.nih.gov/pubmed/37458434
http://dx.doi.org/10.1152/ajpcell.00144.2023

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