Colocalization of expression transcripts with COVID-19 outcomes is rare across cell states, cell types and organs

Identifying causal genes at GWAS loci can help pinpoint targets for therapeutic interventions. Expression studies can disentangle such loci but signals from expression quantitative trait loci (eQTLs) often fail to colocalize—which means that the genetic control of measured expression is not shared w...

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Detalles Bibliográficos
Autores principales: Willett, Julian Daniel Sunday, Lu, Tianyuan, Nakanishi, Tomoko, Yoshiji, Satoshi, Butler-Laporte, Guillaume, Zhou, Sirui, Farjoun, Yossi, Richards, J. Brent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511363/
https://www.ncbi.nlm.nih.gov/pubmed/37640912
http://dx.doi.org/10.1007/s00439-023-02590-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511363/
https://www.ncbi.nlm.nih.gov/pubmed/37640912
http://dx.doi.org/10.1007/s00439-023-02590-w

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