Structural basis for the activation of a compact CRISPR-Cas13 nuclease

The CRISPR-Cas13 ribonucleases have been widely applied for RNA knockdown and transcriptional modulation owing to their high programmability and specificity. However, the large size of Cas13 effectors and their non-specific RNA cleavage upon target activation limit the adeno-associated virus based d...

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Detalles Bibliográficos
Autores principales: Deng, Xiangyu, Osikpa, Emmanuel, Yang, Jie, Oladeji, Seye J., Smith, Jamie, Gao, Xue, Gao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511502/
https://www.ncbi.nlm.nih.gov/pubmed/37730702
http://dx.doi.org/10.1038/s41467-023-41501-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511502/
https://www.ncbi.nlm.nih.gov/pubmed/37730702
http://dx.doi.org/10.1038/s41467-023-41501-5

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