Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson’s disease

Chronic neuroinflammation is implicated in the pathogenesis of Parkinson’s disease (PD), one of the most common neurodegenerative diseases. Itaconate, an endogenous metabolite derived from the tricarboxylic acid cycle via immune‐responsive gene 1 activity, may mediate anti-inflammatory responses by...

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Detalles Bibliográficos
Autores principales: Xia, Ning, Madore, Victoria, Albalakhi, Ali, Lin, Sonia, Stimpson, Taylor, Xu, Yuehang, Schwarzschild, Michael A., Bakshi, Rachit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511514/
https://www.ncbi.nlm.nih.gov/pubmed/37730914
http://dx.doi.org/10.1038/s41598-023-42813-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511514/
https://www.ncbi.nlm.nih.gov/pubmed/37730914
http://dx.doi.org/10.1038/s41598-023-42813-8

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