Cargando…

Microglia-dependent neuroprotective effects of 4-octyl itaconate against rotenone-and MPP+-induced neurotoxicity in Parkinson’s disease

Chronic neuroinflammation is implicated in the pathogenesis of Parkinson’s disease (PD), one of the most common neurodegenerative diseases. Itaconate, an endogenous metabolite derived from the tricarboxylic acid cycle via immune‐responsive gene 1 activity, may mediate anti-inflammatory responses by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Ning, Madore, Victoria, Albalakhi, Ali, Lin, Sonia, Stimpson, Taylor, Xu, Yuehang, Schwarzschild, Michael A., Bakshi, Rachit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511514/ https://www.ncbi.nlm.nih.gov/pubmed/37730914 http://dx.doi.org/10.1038/s41598-023-42813-8

Ejemplares similares

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis
por: Henderson, John, et al.
Publicado: (2021)

Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis
por: Yang, Wenchang, et al.
Publicado: (2022)

4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages
por: Diskin, Ciana, et al.
Publicado: (2021)

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease
por: Ojha, Shreesh, et al.
Publicado: (2015)

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
por: Liao, Shan-Ting, et al.
Publicado: (2019)

Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system
por: Xin, Liangjing, et al.
Publicado: (2022)

Involvement of Akt/mTOR in the Neurotoxicity of Rotenone-Induced Parkinson’s Disease Models
por: Zhang, Yu, et al.
Publicado: (2019)

Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson’s disease
por: Srivastava, Pranay, et al.
Publicado: (2023)

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
por: Ribó-Molina, Pau, et al.
Publicado: (2023)

Bacopa Protects against Neurotoxicity Induced by MPP(+) and Methamphetamine
por: Ferrucci, Michela, et al.
Publicado: (2022)

Neuroprotective effects of Danshensu on rotenone-induced Parkinson’s disease models in vitro and in vivo
por: Wang, Tian, et al.
Publicado: (2020)

Neuroprotective effects of linagliptin in a rotenone-induced rat model of Parkinson's disease
por: Abhangi, Kinjal V, et al.
Publicado: (2022)

Neuroprotective effects of curcumin on the cerebellum in a rotenone‐induced Parkinson’s Disease Model
por: Fikry, Heba, et al.
Publicado: (2022)

Neuroprotective and therapeutic effects of calcitriol in rotenone-induced Parkinson’s disease rat model
por: Magdy, Alshimaa, et al.
Publicado: (2022)

Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP(+) Neurotoxicity
por: Baek, Jeong Yeob, et al.
Publicado: (2018)

Itaconic Acid Based Surfactants: I. Synthesis and Characterization of Sodium n-Octyl Sulfoitaconate Diester Anionic Surfactant
por: Xu, Jun, et al.
Publicado: (2016)

4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation
por: Li, Yang, et al.
Publicado: (2020)

4‐octyl Itaconate inhibits lipopolysaccharide (LPS)‐induced osteoarthritis via activating Nrf2 signalling pathway
por: Zhang, Qingchen, et al.
Publicado: (2022)

4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes
por: He, Sunyue, et al.
Publicado: (2023)

Mechanisms underlying the therapeutic effects of 4-octyl itaconate in treating sepsis based on network pharmacology and molecular docking
por: Chen, Maolin, et al.
Publicado: (2022)

Does Serum Urate Change as Parkinson’s Disease Progresses?
por: Hasimoglu, Yasemin G., et al.
Publicado: (2020)

Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease
por: Yuan, Jiawen, et al.
Publicado: (2016)

Curcumin modulation of L-dopa and rasagiline-induced neuroprotection in rotenone model of Parkinson’s disease
por: El-Shamarka, Marwa El-Sayed, et al.
Publicado: (2023)

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide
por: Liu, Hua, et al.
Publicado: (2018)

Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury
por: Zheng, Yuehuan, et al.
Publicado: (2020)

Four-Octyl Itaconate Attenuates UVB-Induced Melanocytes and Keratinocytes Apoptosis by Nrf2 Activation-Dependent ROS Inhibition
por: Xie, Yongyi, et al.
Publicado: (2022)

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
por: Ryan, Tristram A. J., et al.
Publicado: (2023)

Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson’s Disease
por: Ferreira, Carla, et al.
Publicado: (2020)

Ceruloplasmin Protects Against Rotenone-Induced Oxidative Stress and Neurotoxicity
por: Hineno, Akiyo, et al.
Publicado: (2011)

Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach
por: Bisbal, Mariano, et al.
Publicado: (2019)

Rotenone, Paraquat, and Parkinson’s Disease
por: Tanner, Caroline M., et al.
Publicado: (2011)

Involvement of 5-lipoxygenase/cysteinyl leukotriene receptor 1 in rotenone- and MPP+-induced BV2 microglial activation
por: Wang, Yanfang, et al.
Publicado: (2012)

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity
por: Bayer Andersen, Kirsten, et al.
Publicado: (2016)

4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling
por: Xu, Lujun, et al.
Publicado: (2023)

4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2
por: Diskin, Ciana, et al.
Publicado: (2023)

Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells
por: Ramkumar, Muthu, et al.
Publicado: (2017)

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism
por: Chiu, Ching-Chi, et al.
Publicado: (2014)

Wld(S )but not Nmnat1 protects dopaminergic neurites from MPP(+ )neurotoxicity
por: Antenor-Dorsey, Jo Ann V, et al.
Publicado: (2012)

Protective effects of polyphenol-rich extracts against neurotoxicity elicited by paraquat or rotenone in cellular models of Parkinson’s disease
por: Tambe, Mitali A., et al.
Publicado: (2023)

Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson’s Disease
por: Tambe, Mitali A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2ud2slmmeq8sl6c9p4lhklg4af