Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform

Monoclonal antibodies (mAbs) eliminate cancer cells via various effector mechanisms including antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are influenced by the N-glycan structures on the Fc region of mAbs. Manipulating these glycan structur...

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Detalles Bibliográficos
Autores principales: Nguyen, Ngan T. B., Leung, Hau Wan, Pang, Kuin Tian, Tay, Shi Jie, Walsh, Ian, Choo, Andre B. H., Yang, Yuansheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511539/
https://www.ncbi.nlm.nih.gov/pubmed/37731040
http://dx.doi.org/10.1038/s41598-023-42925-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511539/
https://www.ncbi.nlm.nih.gov/pubmed/37731040
http://dx.doi.org/10.1038/s41598-023-42925-1

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