Cargando…

Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform

Monoclonal antibodies (mAbs) eliminate cancer cells via various effector mechanisms including antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are influenced by the N-glycan structures on the Fc region of mAbs. Manipulating these glycan structur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Ngan T. B., Leung, Hau Wan, Pang, Kuin Tian, Tay, Shi Jie, Walsh, Ian, Choo, Andre B. H., Yang, Yuansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511539/ https://www.ncbi.nlm.nih.gov/pubmed/37731040 http://dx.doi.org/10.1038/s41598-023-42925-1

Ejemplares similares

Multiplexed engineering glycosyltransferase genes in CHO cells via targeted integration for producing antibodies with diverse complex-type N-glycans
por: Nguyen, Ngan T. B., et al.
Publicado: (2021)

Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics
por: Pang, Kuin Tian, et al.
Publicado: (2021)

Development and evaluation of a new, specially tailored CHO media platform
por: Beckmann, Tim F, et al.
Publicado: (2013)

Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells
por: Ong, Han Kee, et al.
Publicado: (2022)

Computational Modeling of O-Linked Glycan Biosynthesis in CHO Cells
por: Kouka, Thukaa, et al.
Publicado: (2022)

Engineering of CHO Cells for the Production of Recombinant Glycoprotein Vaccines with Xylosylated N-glycans
por: Sandig, Grit, et al.
Publicado: (2017)

Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile
por: Legmann, Rachel, et al.
Publicado: (2011)

Shotgun Glycomics Identifies Tumor-Associated Glycan Ligands Bound by an Ovarian Carcinoma-Specific Monoclonal Antibody
por: Liau, B., et al.
Publicado: (2017)

Stress‐induced increase of monoclonal antibody production in CHO cells
por: Schellenberg, Jana, et al.
Publicado: (2022)

A multi-landing pad DNA integration platform for mammalian cell engineering
por: Gaidukov, Leonid, et al.
Publicado: (2018)

Enhancement of effector functions of anti-CD20 monoclonal antibody by increased afucosylation in CHO cell line through cell culture medium optimization
por: Bheemareddy, Bala Reddy, et al.
Publicado: (2022)

Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform
por: Ghorbaniaghdam, Atefeh, et al.
Publicado: (2014)

Selective growth-inhibition of multidrug-resistant CHO-cells by the monoclonal antibody 265/F4.
por: Efferth, T., et al.
Publicado: (1991)

Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies
por: Aoyama, Michihiko, et al.
Publicado: (2019)

Comparison of Internal Ribosome Entry Site (IRES) and Furin-2A (F2A) for Monoclonal Antibody Expression Level and Quality in CHO Cells
por: Ho, Steven C. L., et al.
Publicado: (2013)

Correction: Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform
Publicado: (2014)

Multi-omics approach for comparative studies of monoclonal antibody producing CHO cells
por: Orellana, Camila A, et al.
Publicado: (2015)

Characterization of H type 1 and type 1 N-acetyllactosamine glycan epitopes on ovarian cancer specifically recognized by the anti-glycan monoclonal antibody mAb-A4
por: Choo, Matthew, et al.
Publicado: (2017)

Precision Landing Tests of Tethered Multicopter and VTOL UAV on Moving Landing Pad on a Lake
por: Kownacki, Cezary, et al.
Publicado: (2023)

Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells
por: Kochanowski, Nadine, et al.
Publicado: (2011)

GlycanAnalyzer: software for automated interpretation of N-glycan profiles after exoglycosidase digestions
por: Walsh, Ian, et al.
Publicado: (2019)

GlycanAnalyzer: software for automated interpretation of N-glycan profiles after exoglycosidase digestions
por: Walsh, Ian, et al.
Publicado: (2019)

Preliminary evaluation of microcarrier culture for growth and monoclonal antibody production of CHO-K1 cells
por: Rodrigues, M Elisa, et al.
Publicado: (2011)

Reduction in C-terminal amidated species of recombinant monoclonal antibodies by genetic modification of CHO cells
por: Škulj, Mihaela, et al.
Publicado: (2014)

Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody
por: Carrillo-Cocom, L. M., et al.
Publicado: (2014)

An Onboard Vision-Based System for Autonomous Landing of a Low-Cost Quadrotor on a Novel Landing Pad
por: Liu, Xuancen, et al.
Publicado: (2019)

Hitting the Sweet Spot: Glycans as Targets of Fungal Defense Effector Proteins
por: Künzler, Markus
Publicado: (2015)

Release of protein N-glycans by effectors of a Hofmann carboxamide rearrangement
por: Kasim, Mumtaz, et al.
Publicado: (2022)

Study of a recombinant CHO cell line producing a monoclonal antibody by ATF or TFF external filter perfusion in a WAVE Bioreactor™
por: Clincke, Marie-Françoise, et al.
Publicado: (2011)

The DFR locus: A smart landing pad for targeted transgene insertion in tomato
por: Danilo, Benoit, et al.
Publicado: (2018)

Differential affects of low glucose on the macroheterogeneity and microheterogeneity of glycosylation in CHO-EG2 camelid monoclonal antibodies
por: Liu, Bo, et al.
Publicado: (2013)

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies
por: Noh, Soo Min, et al.
Publicado: (2018)

Monoclonal antibodies expression improvement in CHO cells by PiggyBac transposition regarding vectors ratios and design
por: Ahmadi, Samira, et al.
Publicado: (2017)

Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
por: Mahé, Amélie, et al.
Publicado: (2021)

Novel application of anti‐human Fc nanobody for screening high‐producing CHO cells for monoclonal antibody
por: Zhu, Di, et al.
Publicado: (2022)

Comparing different domains of analysis for the characterisation of N-glycans on monoclonal antibodies
por: Carillo, Sara, et al.
Publicado: (2020)

USP Reference Standard Monoclonal Antibodies: Tools to Verify Glycan Structure
por: Guo, Jingzhong, et al.
Publicado: (2022)

Single use bioreactors for the clinical production of monoclonal antibodies – a study to analyze the performance of a CHO cell line and the quality of the produced monoclonal antibody
por: Diekmann, Sonja, et al.
Publicado: (2011)

Enhancing and stabilizing monoclonal antibody production by Chinese hamster ovary (CHO) cells with optimized perfusion culture strategies
por: Liang, Kexue, et al.
Publicado: (2023)

Expression of ASFV p17 in CHO cells and identification of one novel epitope using a monoclonal antibody
por: Li, Liwei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9keavge1p0k4a1b2j0epjes1i1