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Synergism between CMG helicase and leading strand DNA polymerase at replication fork

The replisome that replicates the eukaryotic genome consists of at least three engines: the Cdc45-MCM-GINS (CMG) helicase that separates duplex DNA at the replication fork and two DNA polymerases, one on each strand, that replicate the unwound DNA. Here, we determined a series of cryo-electron micro...

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Detalles Bibliográficos
Autores principales: Xu, Zhichun, Feng, Jianrong, Yu, Daqi, Huo, Yunjing, Ma, Xiaohui, Lam, Wai Hei, Liu, Zheng, Li, Xiang David, Ishibashi, Toyotaka, Dang, Shangyu, Zhai, Yuanliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511561/
https://www.ncbi.nlm.nih.gov/pubmed/37730685
http://dx.doi.org/10.1038/s41467-023-41506-0