Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors

Apoptosis plays a crucial role in cancer pathogenesis and drug resistance. BCL-2 family of enzymes is considered as one of the key enzymes which is involved in apoptosis. When there is disruption in the balance between anti-apoptotic and pro-apoptotic members of the BCL-2 family apoptosis is dysregu...

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Detalles Bibliográficos
Autores principales: Ismail, Hoda S., Khalil, Amira, Taha, Rabah A., Lasheen, Deena S., Abou El Ella, Dalal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511702/
https://www.ncbi.nlm.nih.gov/pubmed/37730790
http://dx.doi.org/10.1038/s41598-023-41783-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511702/
https://www.ncbi.nlm.nih.gov/pubmed/37730790
http://dx.doi.org/10.1038/s41598-023-41783-1

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