Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase

Xanthine oxidoreductase is a metalloenzyme that catalyzes the final steps in purine metabolism by converting hypoxanthine to xanthine and then uric acid. Allopurinol, an analog of hypoxanthine, is widely used as an antigout drug, as xanthine oxidoreductase-mediated metabolism of allopurinol to oxypu...

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Detalles Bibliográficos
Autores principales: Sekine, Mai, Okamoto, Ken, Pai, Emil F., Nagata, Koji, Ichida, Kimiyoshi, Hille, Russ, Nishino, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511816/
https://www.ncbi.nlm.nih.gov/pubmed/37625592
http://dx.doi.org/10.1016/j.jbc.2023.105189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511816/
https://www.ncbi.nlm.nih.gov/pubmed/37625592
http://dx.doi.org/10.1016/j.jbc.2023.105189

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