Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s physicochemical properties and biological potency. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Prashant, Wang, Michael, Kumru, Ozan S., Hickey, John M., Sanmiguel, Julio, Zabaleta, Nerea, Vandenberghe, Luk H., Joshi, Sangeeta B., Volkin, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512015/
https://www.ncbi.nlm.nih.gov/pubmed/37746246
http://dx.doi.org/10.1016/j.omtm.2023.06.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512015/
https://www.ncbi.nlm.nih.gov/pubmed/37746246
http://dx.doi.org/10.1016/j.omtm.2023.06.004

Ejemplares similares