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Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate
Recombinant adeno-associated viruses (rAAVs) are a preferred vector system in clinical gene transfer. A fundamental challenge to formulate and deliver rAAVs as stable and efficacious vaccines is to elucidate interrelationships between the vector’s physicochemical properties and biological potency. T...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512015/ https://www.ncbi.nlm.nih.gov/pubmed/37746246 http://dx.doi.org/10.1016/j.omtm.2023.06.004 |