Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the potential neurotoxicity of chemicals before their release in the market, needs to be replaced by new approach methodologies. To illustrate the use of new approach methodologies, the human induced pluripoten...

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Detalles Bibliográficos
Autores principales: Nunes, Carolina, Proença, Susana, Ambrosini, Giovanna, Pamies, David, Thomas, Aurélien, Kramer, Nynke I., Zurich, Marie-Gabrielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512064/
https://www.ncbi.nlm.nih.gov/pubmed/37745076
http://dx.doi.org/10.3389/fphar.2023.1248882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512064/
https://www.ncbi.nlm.nih.gov/pubmed/37745076
http://dx.doi.org/10.3389/fphar.2023.1248882

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