Cargando…

Comprehensive profiling of pre-infection antibodies identifies HIV targets associated with viremic control and viral load

BACKGROUND: High HIV viral load (VL) is associated with increased transmission risk and faster disease progression. HIV controllers achieve viral suppression without antiretroviral (ARV) treatment. We evaluated viremic control in a community-randomized trial with >48,000 participants. METHODS: A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grant-McAuley, Wendy, Morgenlander, William, Hudelson, Sarah E., Thakar, Manjusha, Piwowar-Manning, Estelle, Clarke, William, Breaud, Autumn, Blankson, Joel, Wilson, Ethan, Ayles, Helen, Bock, Peter, Moore, Ayana, Kosloff, Barry, Shanaube, Kwame, Meehan, Sue-Ann, van Deventer, Anneen, Fidler, Sarah, Hayes, Richard, Ruczinski, Ingo, Kammers, Kai, Laeyendecker, Oliver, Larman, H. Benjamin, Eshleman, Susan H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512082/ https://www.ncbi.nlm.nih.gov/pubmed/37744365 http://dx.doi.org/10.3389/fimmu.2023.1178520

Ejemplares similares

Evaluation of multi-assay algorithms for identifying individuals with recent HIV infection: HPTN 071 (PopART)
por: Grant-McAuley, Wendy, et al.
Publicado: (2021)

Evaluation of multi-assay algorithms for cross-sectional HIV incidence estimation in settings with universal antiretroviral treatment
por: Grant-McAuley, Wendy, et al.
Publicado: (2022)

Population‐level analysis of natural control of HIV infection in Zambia and South Africa: HPTN 071 (PopART)
por: Grant‐McAuley, Wendy, et al.
Publicado: (2023)

HIV Antibody Profiles in HIV Controllers and Persons With Treatment-Induced Viral Suppression
por: Kammers, Kai, et al.
Publicado: (2021)

Antiretroviral Drug Detection in a Community-Randomized Trial of Universal HIV Testing and Treatment: HPTN 071 (PopART)
por: Fogel, Jessica M, et al.
Publicado: (2022)

HIV drug resistance in a community‐randomized trial of universal testing and treatment: HPTN 071 (PopART)
por: Fogel, Jessica M., et al.
Publicado: (2022)

Determination of HIV status and identification of incident HIV infections in a large, community‐randomized trial: HPTN 071 (PopART)
por: Eshleman, Susan H, et al.
Publicado: (2020)

Validation of population‐level HIV‐1 incidence estimation by cross‐sectional incidence assays in the HPTN 071 (PopART) trial
por: Klock, Ethan, et al.
Publicado: (2021)

Community‐ and individual‐level correlates of HIV incidence in HPTN 071 (PopART)
por: Skalland, Timothy, et al.
Publicado: (2023)

Detecting antibody reactivities in Phage ImmunoPrecipitation Sequencing data
por: Chen, Athena, et al.
Publicado: (2022)

Detecting and quantifying antibody reactivity in PhIP-Seq data with BEER
por: Chen, Athena, et al.
Publicado: (2022)

Understanding low sensitivity of community-based HIV rapid testing: experiences from the HPTN 071 (PopART) trial in Zambia and South Africa
por: Bock, Peter, et al.
Publicado: (2017)

Assessing usability of QIAreach QuantiFERON-TB platform in a high tuberculosis prevalence, low-resource setting
por: Kaaba, Conceptor, et al.
Publicado: (2021)

Impact of universal testing and treatment on sexual risk behaviour and herpes simplex virus type 2: a prespecified secondary outcomes analysis of the HPTN 071 (PopART) community-randomised trial
por: Wilson, Ethan, et al.
Publicado: (2022)

Comprehensive Profiling of HIV Antibody Evolution
por: Eshleman, Susan H., et al.
Publicado: (2019)

Antiretroviral drug use and HIV drug resistance in female sex workers in Tanzania and the Dominican Republic
por: Grant-McAuley, Wendy, et al.
Publicado: (2020)

Sexually Transmitted Bedfellows: Exquisite Association Between HIV and Herpes Simplex Virus Type 2 in 21 Communities in Southern Africa in the HIV Prevention Trials Network 071 (PopART) Study
por: Bradley, John, et al.
Publicado: (2018)

A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial
por: Hayes, Richard, et al.
Publicado: (2017)

Transplantation of HCV Viremic Livers into HCV Viremic Recipients Followed by Direct-acting Antiviral Therapy
por: Kapila, Nikhil, et al.
Publicado: (2019)

Viral suppression and self-reported ART adherence after 3 years of universal testing and treatment in the HPTN 071 (PopART) community-randomised trial in Zambia and South Africa: a cross-sectional analysis
por: Macleod, David, et al.
Publicado: (2022)

Prevalence and risk factors of M tuberculosis infection in young people across 14 communities in Zambia and South Africa
por: Amofa-Sekyi, Modupe, et al.
Publicado: (2023)

The impact of a combined TB/HIV intervention on the incidence of TB infection among adolescents and young adults in the HPTN 071 (PopART) trial communities in Zambia and South Africa
por: Shanaube, Kwame, et al.
Publicado: (2023)

Field comparison of OraQuick® ADVANCE Rapid HIV-1/2 antibody test and two blood-based rapid HIV antibody tests in Zambia
por: Zachary, Dalila, et al.
Publicado: (2012)

Impact of a community-wide combination HIV prevention intervention on knowledge of HIV status among adolescents
por: Shanaube, Kwame, et al.
Publicado: (2021)

Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients
por: Witwer, Kenneth W, et al.
Publicado: (2012)

Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn
por: Liebhoff, Anna-Maria, et al.
Publicado: (2023)

HIV-1 Transmission during Early Antiretroviral Therapy: Evaluation of Two HIV-1 Transmission Events in the HPTN 052 Prevention Study
por: Ping, Li-Hua, et al.
Publicado: (2013)

Community intervention improves knowledge of HIV status of adolescents in Zambia: findings from HPTN 071-PopART for youth study
por: Shanaube, Kwame, et al.
Publicado: (2017)

What works – reaching universal HIV testing: lessons from HPTN 071 (PopART) trial in Zambia
por: Shanaube, Kwame, et al.
Publicado: (2017)

Depressive symptoms and HIV risk behaviours among adolescents enrolled in the HPTN071 (PopART) trial in Zambia and South Africa
por: Shanaube, Kwame, et al.
Publicado: (2022)

Outcome of Kidney Transplants from Viremic and Non-Viremic Hepatitis C Virus Positive Donors into Negative Recipients: Results of the Spanish Registry
por: Franco, Antonio, et al.
Publicado: (2023)

A Comprehensive Genomics Solution for HIV Surveillance and Clinical Monitoring in Low-Income Settings
por: Bonsall, David, et al.
Publicado: (2020)

Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality
por: Morgenlander, William, et al.
Publicado: (2020)

Elite and viremic HIV-1 controllers in West Africa
por: N’takpé, Jean Baptiste, et al.
Publicado: (2022)

SARS-CoV-2 seroprevalence and associated risk factors in periurban Zambia: a population-based study
por: Shanaube, K, et al.
Publicado: (2022)

Optimising Xpert-Ultra and culture testing to reliably measure tuberculosis prevalence in the community: findings from surveys in Zambia and South Africa
por: Floyd, Sian, et al.
Publicado: (2022)

Tuberculosis prevalence after 4 years of population-wide systematic TB symptom screening and universal testing and treatment for HIV in the HPTN 071 (PopART) community-randomised trial in Zambia and South Africa: A cross-sectional survey (TREATS)
por: Klinkenberg, Eveline, et al.
Publicado: (2023)

Effect of Natural and ARV-Induced Viral Suppression and Viral Breakthrough on Anti-HIV Antibody Proportion and Avidity in Patients with HIV-1 Subtype B Infection
por: Wendel, Sarah K., et al.
Publicado: (2013)

Towards 90-90: Findings after two years of the HPTN 071 (PopART) cluster-randomized trial of a universal testing-and-treatment intervention in Zambia
por: Floyd, Sian, et al.
Publicado: (2018)

HIV Care Cascade Among Adolescents in a “Test and Treat” Community-Based Intervention: HPTN 071 (PopART) for Youth Study
por: Shanaube, Kwame, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sag5klj4t2f8j8aovgb10kl7kp