Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B)

BACKGROUND: Abemaciclib-induced diarrhea (AID) impairs quality of life (QOL) and treatment adherence in patients with breast cancer. Supportive treatment with loperamide is associated with constipation. We hypothesized that probiotics and trimebutine maleate (TM) would decrease the frequency of AID...

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Detalles Bibliográficos
Autores principales: Masuda, Hiroko, Tanabe, Yuko, Sakai, Hitomi, Matsumoto, Koji, Shimomura, Akihiko, Doi, Mihoko, Miyoshi, Yasuo, Takahashi, Masato, Sagara, Yasuaki, Tokunaga, Shinya, Iwasa, Tsutomu, Niikura, Naoki, Yoshimura, Kenichi, Takano, Toshimi, Tsurutani, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512094/
https://www.ncbi.nlm.nih.gov/pubmed/37459790
http://dx.doi.org/10.1016/j.breast.2023.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512094/
https://www.ncbi.nlm.nih.gov/pubmed/37459790
http://dx.doi.org/10.1016/j.breast.2023.07.003

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