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Efficacy of probiotics and trimebutine maleate for abemaciclib-induced diarrhea: A randomized, open-label phase II trial (MERMAID, WJOG11318B)
BACKGROUND: Abemaciclib-induced diarrhea (AID) impairs quality of life (QOL) and treatment adherence in patients with breast cancer. Supportive treatment with loperamide is associated with constipation. We hypothesized that probiotics and trimebutine maleate (TM) would decrease the frequency of AID...
Autores principales: | Masuda, Hiroko, Tanabe, Yuko, Sakai, Hitomi, Matsumoto, Koji, Shimomura, Akihiko, Doi, Mihoko, Miyoshi, Yasuo, Takahashi, Masato, Sagara, Yasuaki, Tokunaga, Shinya, Iwasa, Tsutomu, Niikura, Naoki, Yoshimura, Kenichi, Takano, Toshimi, Tsurutani, Junji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512094/ https://www.ncbi.nlm.nih.gov/pubmed/37459790 http://dx.doi.org/10.1016/j.breast.2023.07.003 |
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