Pharmacokinetics and safety of highly variable valsartan in single-pill combination with amlodipine versus its generic formulation: a randomized, three-cycle, three-sequence, partially replicated crossover phase I bioequivalence clinical trial

Valsartan/amlodipine (I) is a single-pill combination (SPC) of an angiotensin II receptor blocker (ARB) and a calcium channel blocker (CCB) for treating hypertension. A clinical trial was performed to demonstrate that the test and reference valsartan/amlodipine formulations were bioequivalent under...

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Detalles Bibliográficos
Autores principales: Qiu, Bo, Song, Haojing, Ding, Congyang, Sun, Xue, Du, Runxuan, Yang, Haotian, Bai, Wanjun, Dong, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512707/
https://www.ncbi.nlm.nih.gov/pubmed/37745062
http://dx.doi.org/10.3389/fphar.2023.1264321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512707/
https://www.ncbi.nlm.nih.gov/pubmed/37745062
http://dx.doi.org/10.3389/fphar.2023.1264321

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