The intracerebral injection of Aβ(1-42) oligomers does not invariably alter seizure susceptibility in mice

OBJECTIVES: Epileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ(1-42)) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these Aβ(1-42...

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Detalles Bibliográficos
Autores principales: Vande Vyver, Maxime, Daeninck, Louise, De Smet, Gino, Aourz, Najat, Sahu, Surajit, Engelborghs, Sebastiaan, Pauwels, Kris, De Bundel, Dimitri, Smolders, Ilse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512828/
https://www.ncbi.nlm.nih.gov/pubmed/37744393
http://dx.doi.org/10.3389/fnagi.2023.1239140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512828/
https://www.ncbi.nlm.nih.gov/pubmed/37744393
http://dx.doi.org/10.3389/fnagi.2023.1239140

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