Cargando…

The intracerebral injection of Aβ(1-42) oligomers does not invariably alter seizure susceptibility in mice

OBJECTIVES: Epileptiform activity and seizures are present in patients with Alzheimer’s disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ(1-42)) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these Aβ(1-42...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vande Vyver, Maxime, Daeninck, Louise, De Smet, Gino, Aourz, Najat, Sahu, Surajit, Engelborghs, Sebastiaan, Pauwels, Kris, De Bundel, Dimitri, Smolders, Ilse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512828/ https://www.ncbi.nlm.nih.gov/pubmed/37744393 http://dx.doi.org/10.3389/fnagi.2023.1239140

Ejemplares similares

Higher susceptibility to 6 Hz corneal kindling and lower responsiveness to antiseizure drugs in mouse models of Alzheimer's disease
por: Vande Vyver, Maxime, et al.
Publicado: (2022)

Melatonin levels in the Alzheimer’s disease continuum: a systematic review
por: Nous, Amber, et al.
Publicado: (2021)

Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1
por: Van Den Herrewegen, Yana, et al.
Publicado: (2021)

The prion-like transmission of tau oligomers via exosomes
por: Jackson, Noel A., et al.
Publicado: (2022)

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor
por: Coppens, Jessica, et al.
Publicado: (2017)

Underlying microangiopathy and functional outcome of simultaneous multiple intracerebral hemorrhage
por: Li, Jiawen, et al.
Publicado: (2022)

Targeting the Ghrelin Receptor as a Novel Therapeutic Option for Epilepsy
por: Buckinx, An, et al.
Publicado: (2021)

Age-related differences in risk factors, clinical characteristics, and outcomes for intracerebral hemorrhage
por: Chen, Chu, et al.
Publicado: (2023)

Glibenclamide Attenuates Neuroinflammation and Promotes Neurological Recovery After Intracerebral Hemorrhage in Aged Rats
por: Jiang, Bing, et al.
Publicado: (2021)

A Novel Coagulation Classification and Postoperative Bleeding in Severe Spontaneous Intracerebral Hemorrhage Patients on Antiplatelet Therapy
por: Liu, Qingyuan, et al.
Publicado: (2022)

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage
por: Wu, Moxin, et al.
Publicado: (2023)

Scalp Acupuncture Attenuates Brain Damage After Intracerebral Hemorrhage Through Enhanced Mitophagy and Reduced Apoptosis in Rats
por: Liu, Peng, et al.
Publicado: (2021)

TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage
por: Liu, Sidan, et al.
Publicado: (2022)

Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
por: Wang, Ziyu, et al.
Publicado: (2023)

Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE
por: Gao, Yuan, et al.
Publicado: (2023)

Psychedelic-Induced Serotonin 2A Receptor Downregulation Does Not Predict Swim Stress Coping in Mice
por: Pędzich, Błażej D., et al.
Publicado: (2022)

Stoichiometry of HLA Class II-Invariant Chain Oligomers
por: Koch, Norbert, et al.
Publicado: (2011)

Effects of α-Lipoic Acid on Phagocytosis of Oligomeric Beta-Amyloid(1–42) in BV-2 Mouse Microglial Cells
por: Ko, Chih-Yuan, et al.
Publicado: (2022)

Inhibiting amyloid beta (1–42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex
por: Olajide, Olayemi Joseph, et al.
Publicado: (2022)

Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks
por: Zhang, Yuting, et al.
Publicado: (2022)

Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers
por: Chang, Han-Wen, et al.
Publicado: (2022)

Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection
por: De Bundel, Dimitri, et al.
Publicado: (2008)

Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid
por: Custers, Marie-Laure, et al.
Publicado: (2022)

Elevated serum nuclear factor erythroid 2-related factor 2 levels contribute to a poor prognosis after acute supratentorial intracerebral hemorrhage: A prospective cohort study
por: Wang, Chuan-Liu, et al.
Publicado: (2022)

Capping of Aβ42 Oligomers by Small Molecule Inhibitors
por: Fu, Ziao, et al.
Publicado: (2014)

Effect of Lauric Acid on the Stability of Aβ(42) Oligomers
por: Khatua, Prabir, et al.
Publicado: (2021)

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity
por: Izzo, Nicholas J., et al.
Publicado: (2014)

Apolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels
por: Holden, Sarah, et al.
Publicado: (2022)

Associations between blood-based biomarkers of Alzheimer’s disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau
por: Chen, Pei-Hao, et al.
Publicado: (2022)

Corrigendum: Associations between blood-based biomarkers of Alzheimer's disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau
por: Chen, Pei-Hao, et al.
Publicado: (2023)

Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory
por: Walrave, Laura, et al.
Publicado: (2016)

Early-start antiplatelet therapy after operation in patients with spontaneous intracerebral hemorrhage and high risk of ischemic events (E-start): Protocol for a multi-centered, prospective, open-label, blinded endpoint randomized controlled trial
por: Wang, Kaiwen, et al.
Publicado: (2022)

Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
por: Ahmed, Mahiuddin, et al.
Publicado: (2010)

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution
por: Wolff, Martin, et al.
Publicado: (2017)

Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers
por: Banerjee, Siddhartha, et al.
Publicado: (2020)

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits
por: Izzo, Nicholas J., et al.
Publicado: (2014)

Targeting firing rate neuronal homeostasis can prevent seizures
por: Mulroe, Fred, et al.
Publicado: (2022)

Serum Daytime Melatonin Levels Reflect Cerebrospinal Fluid Melatonin Levels in Alzheimer’s Disease but Are Not Correlated with Cognitive Decline
por: Nous, Amber, et al.
Publicado: (2021)

Structure of ring-shaped Aβ(42) oligomers determined by conformational selection
por: Tran, Linh, et al.
Publicado: (2016)

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers
por: Novo, Mercedes, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0a1t4rdggiqljkpv0mqua2amkb