Impact of amiodarone use on metoprolol concentrations, α‐OH‐metoprolol concentrations, metoprolol dosing and heart rate: A cross‐sectional study

Small studies suggest that amiodarone is a weak inhibitor of cytochrome P450 (CYP) 2D6. Inhibition of CYP2D6 leads to increases in concentrations of drugs metabolized by the enzyme, such as metoprolol. Considering that both metoprolol and amiodarone have β‐adrenergic blocking properties and that the...

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Detalles Bibliográficos
Autores principales: Robert, Sabrina, Pilon, Marc‐Olivier, Oussaïd, Essaïd, Meloche, Maxime, Leclair, Grégoire, Jutras, Martin, Gaulin, Marie‐Josée, Mongrain, Ian, Busseuil, David, Tardif, Jean‐Claude, Dubé, Marie‐Pierre, de Denus, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512912/
https://www.ncbi.nlm.nih.gov/pubmed/37732835
http://dx.doi.org/10.1002/prp2.1137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512912/
https://www.ncbi.nlm.nih.gov/pubmed/37732835
http://dx.doi.org/10.1002/prp2.1137

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