Epithelial NAD(+) depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

INTRODUCTION: We have previously demonstrated that a pathologic downregulation of peroxisome proliferator-activated receptor–gamma coactivator 1-alpha (PGC1α) within the intestinal epithelium contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanism underlying downr...

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Detalles Bibliográficos
Autores principales: Novak, Elizabeth A., Crawford, Erin C., Mentrup, Heather L., Griffith, Brian D., Fletcher, David M., Flanagan, Meredith R., Schneider, Corinne, Firek, Brian, Rogers, Matthew B., Morowitz, Michael J., Piganelli, Jon D., Wang, Qian, Mollen, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512956/
https://www.ncbi.nlm.nih.gov/pubmed/37744380
http://dx.doi.org/10.3389/fimmu.2023.1231700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512956/
https://www.ncbi.nlm.nih.gov/pubmed/37744380
http://dx.doi.org/10.3389/fimmu.2023.1231700

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