Novel bimodal TRBD1-TRBD2 rearrangements with dual or absent D-region contribute to TRB V-(D)-J combinatorial diversity

T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangement of a TRBV gene to the partially rearranged D-J...

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Detalles Bibliográficos
Autores principales: Smirnova, Anastasia O., Miroshnichenkova, Anna M., Belyaeva, Laima D., Kelmanson, Ilya V., Lebedev, Yuri B., Mamedov, Ilgar Z., Chudakov, Dmitriy M., Komkov, Alexander Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513440/
https://www.ncbi.nlm.nih.gov/pubmed/37744336
http://dx.doi.org/10.3389/fimmu.2023.1245175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513440/
https://www.ncbi.nlm.nih.gov/pubmed/37744336
http://dx.doi.org/10.3389/fimmu.2023.1245175

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