Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases. This study presents the identification of a potent DHODH inhibitor by proteomic profiling. Cell-based screening...

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Detalles Bibliográficos
Autores principales: KAWATANI, MAKOTO, AONO, HARUMI, HIRANUMA, SAYOKO, SHIMIZU, TAKESHI, MUROI, MAKOTO, NOGAWA, TOSHIHIKO, OHISHI, TOMOKAZU, OHBA, SHUN-ICHI, KAWADA, MANABU, YAMAZAKI, KANAMI, DAN, SHINGO, DOHMAE, NAOSHI, OSADA, HIROYUKI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513951/
https://www.ncbi.nlm.nih.gov/pubmed/37744270
http://dx.doi.org/10.32604/or.2023.030241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513951/
https://www.ncbi.nlm.nih.gov/pubmed/37744270
http://dx.doi.org/10.32604/or.2023.030241

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