ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice

ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in hematopoietic stem and progenitor cells (HSPCs), where it is required for adult hematopoiesis. Heterozygous pathogenic germline ETV6 variants are associated with thrombocytopenia 5 (T5), a poorly understood genetic condition resul...

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Detalles Bibliográficos
Autores principales: Bloom, Mackenzie, Oak, Ninad, Baskin-Doerfler, Rebekah, Feng, Ruopeng, Iacobucci, Ilaria, Baviskar, Pradyumna, Zhao, Xujie, Stroh, Alexa N., Li, Chunliang, Ozark, Patrick, Tillman, Heather S., Li, Yichao, Verbist, Katherine C., Albeituni, Sabrin, Scott, Danny C., King, Moeko T., McKinney-Freeman, Shannon L., Weiss, Mitchell J., Yang, Jun J., Nichols, Kim E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514086/
https://www.ncbi.nlm.nih.gov/pubmed/37522715
http://dx.doi.org/10.1182/bloodadvances.2022009313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514086/
https://www.ncbi.nlm.nih.gov/pubmed/37522715
http://dx.doi.org/10.1182/bloodadvances.2022009313

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