OCE-205, A Novel, Selective Vasopressin Receptor Mixed Agonist-Antagonist: Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics from a Phase 1 Study in Healthy Volunteers

BACKGROUND: OCE-205, a novel, selective vasopressin V1a receptor mixed agonist/antagonist with no V2 receptor activity, may treat the portal hypertension-related complications of end-stage liver disease with an improved therapeutic profile over currently utilized nonselective full-agonist vasopressi...

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Detalles Bibliográficos
Autores principales: Bagger, Yu, Ravis, William R., Harris, Geoff, Bukofzer, Stan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514109/
https://www.ncbi.nlm.nih.gov/pubmed/37606870
http://dx.doi.org/10.1007/s40261-023-01299-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514109/
https://www.ncbi.nlm.nih.gov/pubmed/37606870
http://dx.doi.org/10.1007/s40261-023-01299-y

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