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Acetyl group for proper protection of β-sugar-amino acids used in SPPS

The synthesis of d-glucosamine-1-carboxylic acid based β-sugar amino acids (β-SAAs) is typically performed in nine consecutive steps via an inefficient OAc → Br → CN conversion protocol with low overall yield. Here, we present the improved and more efficient synthesis of both Fmoc-GlcAPC-OH and Fmoc...

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Detalles Bibliográficos
Autores principales: Varga, István, Goldschmidt Gőz, Viktória, Pintér, István, Csámpai, Antal, Perczel, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514111/
https://www.ncbi.nlm.nih.gov/pubmed/37340192
http://dx.doi.org/10.1007/s00726-023-03278-1