Cargando…

PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance

Glioblastoma (GBM) is the most frequent tumor of the central nervous system, and its heterogeneity is a challenge in treatment. This study examined tumoral heterogeneity involving PDGFRA, KIT, and KDR gene amplification (GA) in 4q12 and its association with clinical parameters. Specimens from 22 GBM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carlotto, Bianca Soares, Trevisan, Patricia, Provenzi, Valentina Oliveira, Soares, Fabiano Pasqualotto, Rosa, Rafael Fabiano Machado, Varella-Garcia, Marileila, Zen, Paulo Ricardo Gazzola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514169/ https://www.ncbi.nlm.nih.gov/pubmed/37610648 http://dx.doi.org/10.1007/s12017-023-08749-y

Ejemplares similares

The Pan‐Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA
por: Disel, Umut, et al.
Publicado: (2019)

Intratumoral KIT mutational heterogeneity and recurrent KIT/ PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors
por: Gao, Jing, et al.
Publicado: (2016)

KIT/PDGFRA/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors
por: Hou, Helei, et al.
Publicado: (2020)

Evidence for PDGFRA, PDGFRB and KIT deregulation in an NSCLC patient
por: Negri, T, et al.
Publicado: (2007)

Chromosomal Abnormalities in Patients with Congenital Heart Disease
por: Trevisan, Patrícia, et al.
Publicado: (2013)

Data on quantification of signaling pathways activated by KIT and PDGFRA mutants
por: Bahlawane, Christelle, et al.
Publicado: (2016)

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour
por: Priya, Valli, et al.
Publicado: (2020)

Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma
por: Lassus, H, et al.
Publicado: (2004)

Malignant melanoma of the conjunctiva: a case report with examination of KIT and PDGFRA
por: Terada, Tadashi
Publicado: (2012)

Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations
por: Eliyakin, Nuket, et al.
Publicado: (2015)

KIT and PDGFRa mutational patterns in Sardinian patients with gastrointestinal stromal tumors
por: Palomba, Grazia, et al.
Publicado: (2020)

Fluorescence in situ hybridization (FISH) as an irreplaceable diagnostic tool for Williams-Beuren syndrome in developing countries: a literature review
por: Carlotto, Bianca Soares, et al.
Publicado: (2023)

Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report
por: Yang, Lishu, et al.
Publicado: (2018)

Prognostic impact of PDGFRA gain/amplification and MGMT promoter methylation status in patients with IDH wild-type glioblastoma
por: Higa, Nayuta, et al.
Publicado: (2022)

Anterior laryngeal membrane and 22q11 deletion syndrome
por: Rosa, Rafael Fabiano Machado, et al.
Publicado: (2015)

Cytogenetic profile of patients with Down syndrome in southern Brazil
por: Trevisan, Patrícia, et al.
Publicado: (2014)

Mutational Analysis of c-KIT and PDGFRA in Canine Gastrointestinal Stromal Tumors (GISTs)
por: Morini, Maria, et al.
Publicado: (2022)

Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors
por: Silva, Mara, et al.
Publicado: (2010)

Clinical and morphological profile of aneurysms of the anterior communicating artery treated at a neurosurgical service in Southern Brazil
por: Soares, Fabiano Pasqualotto, et al.
Publicado: (2019)

Tumor size and prognosis in patients with Wilms tumor
por: Provenzi, Valentina Oliveira, et al.
Publicado: (2015)

Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST
por: Astolfi, Annalisa, et al.
Publicado: (2020)

Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
por: Bauer, Sebastian, et al.
Publicado: (2021)

Audiological Findings in Patients with Oculo-Auriculo-Vertebral Spectrum
por: Sleifer, Pricila, et al.
Publicado: (2014)

The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting
por: Maleddu, Alessandra, et al.
Publicado: (2011)

Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors
por: Merkelbach-Bruse, Sabine, et al.
Publicado: (2010)

Prognostic value of KIT/PDGFRA mutations in gastrointestinal stromal tumors: a meta-analysis
por: Zong, Liang, et al.
Publicado: (2014)

Dystrophin deregulation is associated with tumor progression in KIT/PDGFRA mutant gastrointestinal stromal tumors
por: Pantaleo, Maria A, et al.
Publicado: (2014)

Concomitant KIT/BRAF and PDGFRA/BRAF mutations are rare events in gastrointestinal stromal tumors
por: Rossi, Sabrina, et al.
Publicado: (2016)

The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
por: Nannini, Margherita, et al.
Publicado: (2017)

PDGFRA and KIT Mutation Status and Its Association With Clinicopathological Properties, Including DOG1
por: Baskin, Yasemin, et al.
Publicado: (2016)

KIT and PDGFRA Variants and the Survival of Patients with Gastrointestinal Stromal Tumor Treated with Adjuvant Imatinib
por: Joensuu, Heikki
Publicado: (2023)

45,X/46,XY mosaicism: report on 14 patients from a Brazilian hospital. A retrospective study
por: Rosa, Rafael Fabiano Machado, et al.
Publicado: (2014)

Hematological abnormalities and 22q11.2 deletion syndrome
por: Rosa, Rafael Fabiano Machado, et al.
Publicado: (2011)

Erratum to: The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
por: Nannini, Margherita, et al.
Publicado: (2017)

Impact of the KIT/PDGFRA genotype on prognosis in imatinib‐naïve Japanese patients with gastrointestinal stromal tumor
por: Cho, Haruhiko, et al.
Publicado: (2021)

EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines
por: Chakravarty, Debyani, et al.
Publicado: (2017)

Alterations in EGFR and PDGFRA are associated with the localization of contrast-enhancing lesions in glioblastoma
por: Makino, Ryutaro, et al.
Publicado: (2023)

Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay
por: Varella-Garcia, Marileila
Publicado: (2006)

Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations
por: Rizzo, Francesca Maria, et al.
Publicado: (2016)

Gain of FGF4 is a frequent event in KIT/PDGFRA/SDH/RAS‐P WT GIST
por: Urbini, Milena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cu1rm84nncocvrc8m8ek4mikrk