W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state

Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme biosynthesis. Within the transport pathway, a conserved aromatic residue W546 located in each monomer plays a pivotal role in stab...

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Detalles Bibliográficos
Autores principales: Lee, Sang Soo, Park, Jun Gyou, Jang, Eunhong, Choi, Seung Hun, Kim, Subin, Kim, Ji Won, Jin, Mi Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514269/
https://www.ncbi.nlm.nih.gov/pubmed/37735522
http://dx.doi.org/10.1038/s42003-023-05339-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514269/
https://www.ncbi.nlm.nih.gov/pubmed/37735522
http://dx.doi.org/10.1038/s42003-023-05339-3

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