Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies

α-Glucosidase inhibition is an approved treatment for type 2 diabetes mellitus (T2DM). In an attempt to develop novel anti-α-glucosidase agents, two series of substituted imidazo[1,2-c]quinazolines, namely 6a–c and 11a–o, were synthesized using a simple, straightforward synthetic routes. These compo...

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Detalles Bibliográficos
Autores principales: Peytam, Fariba, Hosseini, Faezeh sadat, Hekmati, Malak, Bayati, Bahareh, Moghadam, Mahdis Sadeghi, Emamgholipour, Zahra, Firoozpour, Loghman, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Sadat-Ebrahimi, Seyed Esmaeil, Tehrani, Maliheh Barazandeh, Foroumadi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514295/
https://www.ncbi.nlm.nih.gov/pubmed/37735489
http://dx.doi.org/10.1038/s41598-023-42549-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514295/
https://www.ncbi.nlm.nih.gov/pubmed/37735489
http://dx.doi.org/10.1038/s41598-023-42549-5

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