BRAF(V600E)-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis is poorly characterized. We investigated the impact of short-term (3 days) and long-term (6 months) expression of Braf(V600E) in the intestinal tissue of an inducible mouse model. We show t...

Descripción completa

Detalles Bibliográficos
Autores principales: Rzasa, Paulina, Whelan, Sarah, Farahmand, Pooyeh, Cai, Hong, Guterman, Inna, Palacios-Gallego, Raquel, Undru, Shanthi S., Sandford, Lauren, Green, Caleb, Andreadi, Catherine, Mintseva, Maria, Parrott, Emma, Jin, Hong, Hey, Fiona, Giblett, Susan, Sylvius, Nicolas B., Allcock, Natalie S., Straatman-Iwanowska, Anna, Feuda, Roberto, Tufarelli, Cristina, Brown, Karen, Pritchard, Catrin, Rufini, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514332/
https://www.ncbi.nlm.nih.gov/pubmed/37735514
http://dx.doi.org/10.1038/s42003-023-05331-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514332/
https://www.ncbi.nlm.nih.gov/pubmed/37735514
http://dx.doi.org/10.1038/s42003-023-05331-x

Ejemplares similares