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Gingerols synergize with anthocyanins to induce antioxidant activity in vitro

Oxidative stress caused by free radicals contributes to the pathogenesis of multiple chronic health conditions. Phytochemicals protect against oxidative stress; however, low bioavailability from dietary sources limits their health benefits. This study aimed to assess the effects of anthocyanins and...

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Autores principales: Abdurrahim, Amna Emhemed, Mazurak, Vera C., Chen, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514514/
https://www.ncbi.nlm.nih.gov/pubmed/37743923
http://dx.doi.org/10.3389/fnut.2023.1229015
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author Abdurrahim, Amna Emhemed
Mazurak, Vera C.
Chen, Lingyun
author_facet Abdurrahim, Amna Emhemed
Mazurak, Vera C.
Chen, Lingyun
author_sort Abdurrahim, Amna Emhemed
collection PubMed
description Oxidative stress caused by free radicals contributes to the pathogenesis of multiple chronic health conditions. Phytochemicals protect against oxidative stress; however, low bioavailability from dietary sources limits their health benefits. This study aimed to assess the effects of anthocyanins and gingerols’ combination on the cellular antioxidant response of Caco-2 cells against oxidative stress. A strong synergism was observed for anthocyanin-gingerol (Ac-G) w/w combined ratios of 8:1 and 2:1 (dosages of (1 + 0.125) and (1 + 0.5) μg/mL) in the cellular antioxidant activity (CAA) and cytoprotective effects, with synergistic effect indicator (SE) values of 1.41 and 1.61, respectively. The synergism of Ac-G combinations promoted cellular antioxidant defense systems and cytoprotective effects by reducing the induced GPx enzyme activity, protecting SOD enzyme activity, reducing cellular ROS generation, increasing glutathione content, and inhibiting lipid peroxidation. Thus, Ac-G combinations showed potential in supporting the endogenous antioxidant systems to protect cells from oxidation and restore physiological redox status. The Ac-G formulation is a promising healthy option that can be developed into functional foods or nutraceutical products. Furthermore, it could help address the low bioavailability of these phenolics, as higher effects were achieved when combining the same doses.
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spelling pubmed-105145142023-09-23 Gingerols synergize with anthocyanins to induce antioxidant activity in vitro Abdurrahim, Amna Emhemed Mazurak, Vera C. Chen, Lingyun Front Nutr Nutrition Oxidative stress caused by free radicals contributes to the pathogenesis of multiple chronic health conditions. Phytochemicals protect against oxidative stress; however, low bioavailability from dietary sources limits their health benefits. This study aimed to assess the effects of anthocyanins and gingerols’ combination on the cellular antioxidant response of Caco-2 cells against oxidative stress. A strong synergism was observed for anthocyanin-gingerol (Ac-G) w/w combined ratios of 8:1 and 2:1 (dosages of (1 + 0.125) and (1 + 0.5) μg/mL) in the cellular antioxidant activity (CAA) and cytoprotective effects, with synergistic effect indicator (SE) values of 1.41 and 1.61, respectively. The synergism of Ac-G combinations promoted cellular antioxidant defense systems and cytoprotective effects by reducing the induced GPx enzyme activity, protecting SOD enzyme activity, reducing cellular ROS generation, increasing glutathione content, and inhibiting lipid peroxidation. Thus, Ac-G combinations showed potential in supporting the endogenous antioxidant systems to protect cells from oxidation and restore physiological redox status. The Ac-G formulation is a promising healthy option that can be developed into functional foods or nutraceutical products. Furthermore, it could help address the low bioavailability of these phenolics, as higher effects were achieved when combining the same doses. Frontiers Media S.A. 2023-09-08 /pmc/articles/PMC10514514/ /pubmed/37743923 http://dx.doi.org/10.3389/fnut.2023.1229015 Text en Copyright © 2023 Abdurrahim, Mazurak and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Abdurrahim, Amna Emhemed
Mazurak, Vera C.
Chen, Lingyun
Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
title Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
title_full Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
title_fullStr Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
title_full_unstemmed Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
title_short Gingerols synergize with anthocyanins to induce antioxidant activity in vitro
title_sort gingerols synergize with anthocyanins to induce antioxidant activity in vitro
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514514/
https://www.ncbi.nlm.nih.gov/pubmed/37743923
http://dx.doi.org/10.3389/fnut.2023.1229015
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