Mim8, a novel factor VIIIa mimetic bispecific antibody, shows favorable safety and pharmacokinetics in healthy adults

BACKGROUND: Mim8 (denecimig) is a novel activated coagulation factor VIII-mimetic bispecific antibody that assembles with activated coagulation FIX and FX on the platelet membrane surface. OBJECTIVES: The FRONTIER1 (NCT04204408, NN7769-4513) single ascending dose and the 4882 pharmacokinetic (PK) st...

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Detalles Bibliográficos
Autores principales: Persson, Paula, Amstrup, Anne-Beth, Coester, Hans Veit, Matytsina, Irina, Bas, Selcuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514552/
https://www.ncbi.nlm.nih.gov/pubmed/37745159
http://dx.doi.org/10.1016/j.rpth.2023.102181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514552/
https://www.ncbi.nlm.nih.gov/pubmed/37745159
http://dx.doi.org/10.1016/j.rpth.2023.102181

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