Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR

BACKGROUND: CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory adenosine (ADO). A broad variety of solid cancer types was shown to exploit CD73 overexpression as a suppressive immune checkp...

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Detalles Bibliográficos
Autores principales: Ploeg, Emily Maria, Samplonius, Douwe Freerk, Xiong, Xiao, Ke, Xiurong, Hendriks, Mark Alexander Johannes Martinus, Britsch, Isabel, van Wijngaarden, Anne Paulien, Zhang, Hao, Helfrich, Wijnand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514638/
https://www.ncbi.nlm.nih.gov/pubmed/37734877
http://dx.doi.org/10.1136/jitc-2023-006837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514638/
https://www.ncbi.nlm.nih.gov/pubmed/37734877
http://dx.doi.org/10.1136/jitc-2023-006837

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