Cargando…
Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR
BACKGROUND: CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP) excreted by cancer cells under stress to anti-inflammatory adenosine (ADO). A broad variety of solid cancer types was shown to exploit CD73 overexpression as a suppressive immune checkp...
Autores principales: | Ploeg, Emily Maria, Samplonius, Douwe Freerk, Xiong, Xiao, Ke, Xiurong, Hendriks, Mark Alexander Johannes Martinus, Britsch, Isabel, van Wijngaarden, Anne Paulien, Zhang, Hao, Helfrich, Wijnand |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10514638/ https://www.ncbi.nlm.nih.gov/pubmed/37734877 http://dx.doi.org/10.1136/jitc-2023-006837 |
Ejemplares similares
-
A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer
por: Ploeg, Emily Maria, et al.
Publicado: (2023) -
Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation
por: Hendriks, Mark A. J. M., et al.
Publicado: (2020) -
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis
por: Hendriks, Mark A.J.M., et al.
Publicado: (2021) -
CD73 downregulation by EGFR-targeted liposomal CD73 siRNA potentiates antitumor effect of liposomal doxorubicin in 4T1 tumor-bearing mice
por: Soleimani, Anvar, et al.
Publicado: (2022) -
The Roles of CD73 in Cancer
por: Gao, Zhao-wei, et al.
Publicado: (2014)