Discovery and Characterization of an Acid-Labile Serine-Lysine Cross-Link in Antibody High-Molecular-Weight Species Using a Multipronged Mass Spectrometry Approach

[Image: see text] Characterizing the cross-links responsible for the covalent high-molecular-weight (HMW) species in therapeutic monoclonal antibodies (mAbs) is of great importance as it not only provides a framework for risk assessment but also offers insights for process improvement. However, owin...

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Detalles Bibliográficos
Autores principales: Liu, Gao-Yuan, Zhang, Zhengqi, Yan, Yuetian, Wang, Shunhai, Li, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515106/
https://www.ncbi.nlm.nih.gov/pubmed/37674418
http://dx.doi.org/10.1021/acs.analchem.3c01602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515106/
https://www.ncbi.nlm.nih.gov/pubmed/37674418
http://dx.doi.org/10.1021/acs.analchem.3c01602

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