Strict Interactions of Fifth Letters, Hydrophobic Unnatural Bases, in XenoAptamers with Target Proteins

[Image: see text] XenoAptamers are DNA fragments containing additional letters (unnatural bases, UBs) that bind specifically to their target proteins with high affinities (sub-nanomolar K(D) values). One of the UBs is the highly hydrophobic 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds), which significant...

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Detalles Bibliográficos
Autores principales: Kimoto, Michiko, Tan, Hui Pen, Matsunaga, Ken-ichiro, Binte Mohd Mislan, Nur Afiqah, Kawai, Gota, Hirao, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515488/
https://www.ncbi.nlm.nih.gov/pubmed/37677157
http://dx.doi.org/10.1021/jacs.3c06122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515488/
https://www.ncbi.nlm.nih.gov/pubmed/37677157
http://dx.doi.org/10.1021/jacs.3c06122

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