Mechanosynthesis of Stable Salt Hydrates of Allopurinol with Enhanced Dissolution, Diffusion, and Pharmacokinetics

[Image: see text] Allopurinol (ALO) is a medication that treats gout and kidney stones by lowering uric acid synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits poor aqueous solubility, permeability, and bioavailability. To overcome the bottlenecks of ALO, salts...

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Detalles Bibliográficos
Autores principales: Varsa S, Richu Bagya, Pandey, Noopur, Ghosh, Animesh, Srivastava, Anubha, Puram, Pavan Kumar, Meka, Sai Teja, Chernyshev, Vladimir V., Sanphui, Palash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515590/
https://www.ncbi.nlm.nih.gov/pubmed/37744830
http://dx.doi.org/10.1021/acsomega.3c05263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515590/
https://www.ncbi.nlm.nih.gov/pubmed/37744830
http://dx.doi.org/10.1021/acsomega.3c05263

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