Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

[Image: see text] The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy in chemical biology and drug discovery. The identification of suitable starting points for stabilizing native PPIs and their subsequent elaboration into selective and potent molecular glues...

Descripción completa

Detalles Bibliográficos
Autores principales: Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515640/
https://www.ncbi.nlm.nih.gov/pubmed/37676236
http://dx.doi.org/10.1021/jacs.3c05161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515640/
https://www.ncbi.nlm.nih.gov/pubmed/37676236
http://dx.doi.org/10.1021/jacs.3c05161

Ejemplares similares